|
|
The rest degenerate over the years. During the reproductive years, a gland in the brain generates hormones that cause a new egg to be released from its follicle each month. As the follicle develops, it produces the sex hormones estrogen and progesterone, which thicken the lining of the uterus. This enriched lining is prepared to receive and nourish chastetreeberryextract a fertilized egg, which could develop into chastetreeberryextract a baby. If fertilization does not occur, estrogen and progesterone levels drop, the lining of the uterus breaks down, and menstruation occurs. For reasons unknown, your ovaries gradually begin to decline in hormone chastetreeberryextract production during your mid-30s. In your late 40s, the process accelerates and hormones fluctuate more, causing irregular menstrual cycles and unpredictable episodes of bleeding. By your early to mid-50s, periods finally end altogether. However, chastetreeberryextract estrogen production does not completely stop. The ovaries decrease their output significantly, but still may produce a small amount. Progesterone, the other female hormone, works during the second half of the menstrual cycle to create a lining in the uterus as a viable home for an egg, and to shed the lining if the egg is chastetreeberryextract not fertilized. At mid-cycle, a critical peak of estrogen production alerts the hypothalamus to create more GnRh. This time it tells the pituitary to release its lutenizing hormone (LH) to the ovaries, a trigger that will spur the small explosion that releases the egg from the dominant follicle. Ovulation occurs and the corpus luteum forms to continue estrogen and progesterone production until it dies in the absence of pregnancy. Hormone levels plunge. In perimenopause, the ovaries'' estrogen and progesterone production shifts from one that''s follicle rich (with an emphasis on creating eggs) to one that''s stromal rich (less emphasis on eggs, more on the stroma that holds the eggs together). As a result, the hormonal dance changes. A follicle releases an egg less and less often, so estrogen and progesterone levels drop. The uterus lining ceases to thicken, so there is little or nothing to chastetreeberryextract discharge. chastetreeberryextract Menstruation stops, and the decline of ovarian hormones sparks elevation of pituitary hormones such as the luteinizing hormone. It is suspected that this rise of LH in the pituitary causes hot flashes. In addition, these dramatic changes to the endocrine organs The use in disturbances of the female genital system was first reported more than two thousand years ago. Nowadays ethanolic extracts from the fruit are used for the treatment of mastopathy, premenstrual syndrome and luteal insufficiency-complaints caused by a mild or latent hyperprolactinemia. The mode of action of Vitex agnus-castus extracts was studied in vitro using primary cultures from rat pituitaries as a test system. A dose dependent reduction of prolactin secretion was observed. The effect could be blocked by the dopamine-receptor antagonist, haloperidol, confirming a dopamine agonistic activity of the drug. The prolactin chastetreeberryextract lowering effect of Vitex agnus-castus was also found in in vivo experiments in rats. Clinical studies in patients with premenstrual chastetreeberryextract syndrome, luteal insufficiency, and mastopathy show a simultaneous decrease in the clinical syndrome score and prolactin levels. In the monograph of the Commission E, a daily dosage of 30-40mg of an ethanolic extract of the fruit of Vitex agnus-castus is recommended for the treatment of the premenstrual syndrome, chastetreeberryextract luteal phase defects and other disturbances of the menstrual cycle, as well for the treatment of mastodynia .
|