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The alternative use in disturbances of the female genital system was first reported more than two thousand years ago. Nowadays ethanolic extracts from the fruit are used for the treatment health and product of mastopathy, premenstrual syndrome and luteal insufficiency-complaints caused by a mild or latent hyperprolactinemia. The mode of action of Vitex agnus-castus extracts was studied in vitro using primary cultures from rat pituitaries as a test system. A dose dependent reduction of prolactin secretion was observed. The effect could be blocked by the dopamine-receptor antagonist, haloperidol, confirming a dopamine agonistic activity of the drug. The prolactin lowering effect of Vitex agnus-castus was also found in in vivo experiments in rats. Clinical studies in patients with premenstrual syndrome, luteal insufficiency, alternative and mastopathy show a simultaneous decrease in the clinical syndrome score health and prolactin product levels. In the monograph of the Commission E, a daily dosage of 30-40mg of an ethanolic extract alternative of the fruit of Vitex agnus-castus is recommended for the treatment health of the premenstrual syndrome, luteal phase defects and other disturbances of the menstrual cycle, as well for the treatment of mastodynia . This constant dance of hormones orchestrates our fertility, a dance that changes throughout the month and throughout our lives. Of the millions of follicles (eggs) product in the ovaries, alternative eight to ten mature each month. But, in most cases, only one reaches the point that it ruptures and releases an egg (ovulation). The unused follicles die. After health ovulation, the ruptured follicle reconnects and continues to grow, becoming the corpus luteum. In preparation for fertilization, it produces estrogen product and alternative progesterone to create an extra lining in the uterus. health But after about 12 days, if no fertilization occurs, the corpus luteum dies, and estrogen and progesterone levels plunge. This causes the lining to be expelled. product Menstruation begins. Hormonally, a woman''s period marks the end of the menstrual cycle. A new cycle begins when the hypothalamus, in response to the dramatic drop in estrogen and progesterone levels at the end of the last cycle, sends GnRh (another hormone) to the pituitary, which then releases a new batch of follicle stimulating hormones (FSH) to the ovaries. This stimulates the maturation of a small group of follicles.
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